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Data from perfectly-controlled trials specifically comparing metronidazole administered orally to metronidazole administered vaginally are certainly not accessible.

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Also, the revealed outcomes of one of many mouse research reveal a rise in the incidence of malignant lymphomas and also pulmonary neoplasms connected with life span feeding in the drug. Each one of these results are statistically considerable. Quite a few very long-phrase oral dosing research in the rat are already finished. There have been statistically substantial boosts from the incidence of assorted neoplasms, notably in mammary and hepatic tumors, among female rats administered metronidazole in excess of These observed in the concurrent feminine control groups. Two life time tumorigenicity experiments in hamsters are already done and noted to get destructive.

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While these decrease amounts of publicity are more unlikely to make the prevalent reactions seen with oral metronidazole, the opportunity of these and other reactions cannot be excluded presently.

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